As any state capital, Villahermosa has diverse and varied means of public transportation, which allow touring the city with no inconvenience at all; however, you must always be a bit precautious and consult people you trust (tourist guides, hotel personnel) about the best way of completing your urban itineraries.
Villahermosa, the main city in the State of Tabasco, has an efficient system of bus (called truck - camion - in Mexico) lines and units of collective service, which follow predetermined routes; ask before boarding them, the tickets are pretty economic.
If you would rather have something more private and faster, look for one of the taxis circulating across the city; there are many of them, but you should prefer the vehicles displaying a certificate or circulation licenses, or the cars affiliated to formal firms.
On the other hand, you will find numerous firms renting cars and trucks in Villahermosa. The paperwork is pretty simple and all you need is a driver license and a credit card, in order to guide your own destinations through the roads of the capital of Tabasco.